Anti Ulcer, Anti Secretory and Cytoprotective Effects of Trianthema Decandra in Rats

The herb Trianthema decandra. L (Aizoceae family) mentioned in Siddha Literatures had been studied in rats for its ability to inhibit gastric secretion and to protect the gastric mucosa against injuries caused by pyloric ligation, swim stress, acetic acid and cytodestructive agent ethanol. The extracts derived successively by using solvents of increasing polarity from the root powder of TD (Petroleum Ether Extract, Ethyl Acetate Extract, Alcoholic Extract, and Aqueous Extract) at the dose of 200 mg/Kg, p.o, and Crude powder of its root at the dose of 2g/Kg, p.o, were used in all experiments. Famotidine (20mg/Kg, p.o) was used as a standard anti ulcer drug for comparison. Eth.Ace.Ext and CP only showed significant anti ulcer and anti secretory effects in pyloric ligation, swim stress models and all the four extracts and CP showed pronounced cytoprotective effect in ethanol induced gastric ulcer in rats. Significant effect exhibited by Eth.Ace.Ext in acetic acid induced ulcer study reveals its efficacy in chronic ulcer.